ELA, Volume 11, pp. 115-131, June 2004, abstract. Matrix Inversion and Digraphs: the One Factor Case Thomas Britz, D. Dale Olesky, and Pauline van den Driessche The novel concept of a cyclic sequence of a digraph that has precisely one factor is defined, and is used to characterize the entries of the inverse of a matrix with such a digraph. This leads to a characterization of a strongly sign-nonsingular matrix in terms of cyclic sequences. Nonsingular nearly reducible matrices are a well-known class of matrices having precisely one nonzero diagonal, and a simple expression for the entries of the inverse of such a matrix in terms of cyclic sequences is derived. A consequence is that a nonsingular nearly reducible matrix is strongly sign-nonsingular. Several conditions that are equivalent to the inverse of a nonsingular nearly reducible matrix being nearly reducible are obtained.